Ageing and Physical Function
What we do?
It is increasingly recognised that diabetes and other chronic diseases are characterised by accelerated biological aging, impaired physical function and frailty. Our research investigates which accelerometer measured and self-reported physical activity metrics are most predictive of frailty and premature mortality, and the extent to which physical activity interventions can be used to improve physical function in patient groups that are not currently eligible for referral into rehabilitation pathways, such as type 2 diabetes.
Members
Highlighted Research
Perks J, Zaccardi F, Rayt H, Sayers R, Brady EM, Davies MJ, Rowlands AV, Edwardson CL, Hall A. Device-measured physical activity behaviours, and physical function, in people with type 2 diabetes mellitus and peripheral artery disease: A cross-sectional study. Experimental Gerontology. 2023;178:112207. doi: 10.1016/j.exger.2023.112207
Mickute M, Zaccardi F, Razieh C, Sargeant J, Smith AC, Wilkinson TJ, Young HM, Webb D, Khunti K, Davies MJ, Yates T. Individual frailty phenotype components and mortality in adults with type 2 diabetes: A UK Biobank study. Diabetes Research and Clinical Practice. 2023 Jan 1;195:110155. doi: 10.1016/j.diabres.2022.110155
Rowlands AV, Dempsey PC, Maylor B, Razieh C, Zaccardi F, Davies MJ, Khunti K, Yates T. Self-reported walking pace: A simple screening tool with lowest risk of all-cause mortality in those that ‘walk the talk’. Journal of Sports Sciences. 2023 online first. doi: 10.1080/02640414.2023.2209762
Zaccardi F, Timmins IR, Goldney J, Dudbridge F, Dempsey PC, Davies MJ, Khunti K, Yates T. Self-reported walking pace, polygenic risk scores and risk of coronary artery disease in UK biobank. Nutrition, Metabolism and Cardiovascular Diseases. 2022 Nov 1;32(11):2630-7. doi: 10.1016/j.numecd.2022.08.021
Dempsey PC, Musicha C, Rowlands AV, Davies M, Khunti K, Razieh C, Timmins I, Zaccardi F, Codd V, Nelson CP, Yates T. Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length. Communications Biology. 2022;5(1):381. doi: 10.1038/s42003-022-03323-x
Henson J, Arsenyadis F, Redman E, Brady EM, Coull NA, Edwardson CL, Hall AP, James LJ, Khunti K, Rowlands AV, Stevenson EJ. Relative protein intake and associations with markers of physical function in those with type 2 diabetes. Diabetic Medicine. 2022;39(8):e14851. doi: 10.1111/dme.14851
Ahmad E, Sargeant JA, Yates T, Webb DR, Davies MJ. Type 2 diabetes and impaired physical function: a growing problem. Diabetology. 2022;3(1):30-45. doi: 10.3390/diabetology3010003
Wilkinson TJ, Clarke AL, Nixon DG, Hull KL, Song Y, Burton JO, Yates T, Smith AC. Prevalence and correlates of physical activity across kidney disease stages: an observational multicentre study. Nephrology Dialysis Transplantation. 2021 Apr 1;36(4):641-9. doi: 10.1093/ndt/gfz235
Argyridou S, Zaccardi F, Davies MJ, Khunti K, Yates T. Walking pace improves all-cause and cardiovascular mortality risk prediction: A UK Biobank prognostic study. European journal of preventive cardiology. 2020 Jul 1;27(10):1036-44. doi: 10.1177/2047487319887281
Clarke AL, Zaccardi F, Gould DW, Hull KL, Smith AC, Burton JO, Yates T. Association of self-reported physical function with survival in patients with chronic kidney disease. Clinical Kidney Journal. 2019 Feb;12(1):122-8. doi: 10.1093/ckj/sfy080
Mickute M, Henson J, Rowlands AV, Sargeant JA, Webb D, Hall AP, Edwardson CL, Baldry EL, Brady EM, Khunti K, Davies MJ, Yates T. Device‐measured physical activity and its association with physical function in adults with type 2 diabetes mellitus. Diabet Med 2020. doi: 10.1111/dme.14393