The COMBINE Trial
The COMBINE Trial investigates the physiological and metabolic impact of adding structured exercise to a 12-week high protein low energy diet in South Asians living with type 2 diabetes and obesity. Secondary outcomes will report cardiometabolic (insulin sensitivity) and physical function (strength) measures captured through a range of assessment methods.
The COMBINE trial will recruit 36 South Asian women and men aged 40-65 living with type 2 diabetes and obesity to a 12-week high protein (up to 1.3kg/bodyweight/day) low energy diet with or without supervised structured aerobic and resistance exercise (3 days/week).
The low energy diet (which is actively used to achieve diabetes remission) will use of meal replacements and ongoing macronutrient/calorie targets. Meanwhile, the exercise component will involve a mixture of supervised and independent training (encompassing structured aerobic and resistance exercise).
*There is no control group, all eligible participants will receive the diet intervention.*
Contact
Tel: 0116 258 4312