Diet and Nutrition
What we do?
We have an expanding portfolio of research investigating the effects of novel dietary interventions on cardiometabolic health and how they interact with physical activity. Ongoing examples include investigating whether exercise training can be used to help preserve lean mass and improve cardiac function when combined with a low energy diet for diabetes remission and the impact of plant-based diets on novel biomarkers. This work involves a wide range of collaborators through the BRC, nationally through the NIHR Diet and Activity Research Translation (DART) Collaboration, and internationally through our research networks.
Diet and Activity Research Translation
The vision of the collaboration is to work together to ensure a step change in the quality and quantity of research in diet, nutrition, physical activity, sedentary behaviours, weight management and obesity conducted in England. Although these underpin all the major chronic long-term conditions challenging the NHS, the profile of research in these areas lags behind other clinical areas and a collective "voice" within the academic and clinical community is often lacking.
By working together we will optimise and increase accessibility of tools and resources fit-for-purpose for measurement, and coordinate training events for academics and health care professionals. We will also seek to address unmet research needs and develop a strategic approach to the grand challenges in these research areas for example a life course approach to obesity including both therapeutic and public health preventative approaches. Partners in the collaborative have existing work streams in pharmacotherapy, childhood obesity and bariatric surgery.
Members
Highlighted Research
Dasgupta K, Boulé N, Henson J, Chevalier S, Redman E, Chan D, McCarthy M, Champagne J, Arsenyadis F, Rees J, Da Costa D….Yates T. Remission of type 2 diabetes and improved diastolic function by combining structured exercise with meal replacement and food reintroduction among young adults: the RESET for REMISSION randomised controlled trial protocol. BMJ open. 2022 Sep 1;12(9):e063888. doi: 10.1136/bmjopen-2022-063888
Gulsin GS, Swarbrick DJ, Athithan L, Brady EM….Yates T, Khunti K, Davies MJ, McGann GP. Effects of low-energy diet or exercise on cardiovascular function in working-age adults with type 2 diabetes: a prospective, randomized, open-label, blinded end point trial. Diabetes care. 2020;43(6):1300-10. doi: 10.2337/dc20-0129
Alfuhied A, Gulsin GS, Athithan L, Brady EM, Parke K, Henson J, Redman E, Marsh AM, Yates T, Davies MJ, McCann GP. The impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study. The International Journal of Cardiovascular Imaging. 2022;38(9):2013-23. doi: 10.1007/s10554-022-02578-z
Argyridou S, Bernieh D, Henson J, Edwardson CL, Davies MJ, Khunti K, Suzuki T, Yates T. Associations between physical activity and trimethylamine N-oxide in those at risk of type 2 diabetes. BMJ Open Diabetes Research and Care. 2020 Dec 1;8(2):e001359. doi: 10.1136/bmjdrc-2020-001359
Argyridou S, Davies MJ, Biddle GH, Bernieh D, Suzuki T, Dawkins NP, Rowlands AV, Khunti K, Smith AC, Yates T. Evaluation of an 8-Week Vegan Diet on Plasma Trimethylamine-N-Oxide and Postchallenge Glucose in Adults with Dysglycemia or Obesity, The Journal of Nutrition, 2021. doi: 10.1093/jn/nxab046